Orthopedics

MMI is an experienced provider of imaging core lab services for clinical trials of treatments for osteoarthritis, trauma and deformity.  Since 2000, we have evaluated more than 90 unique implants and surgical procedures for the repair of damaged, diseased or degenerated tissue.  Over our 11-year history, we’ve partnered with over 70 orthopedic companies including 8 of the top 10 global market leaders to evaluate the performance of novel musculoskeletal treatments.  Our analyses and consulting services have facilitated numerous product approvals including several “firsts to market”.  Our experienced team of radiologists and imaging scientists uses the latest quantitative imaging techniques and assessment methods to ensure the most reliable assessment of treatment outcomes.

Experience and Expertise

We specialize in providing objective, quantitative assessments of bone and soft tissue treatments from medical images.  We use validated computer-assisted methods to assess common clinical endpoints including cartilage health, lesion repair, implant integration, implant stability, joint re-alignment, bone density, and fracture fixation.  Our quantitative image analysis methods include 3D cartilage thickness mapping, MR relaxation mapping, joint space analysis, assessment of BMD changes, fusion morphology and analysis of fracture risk and degree of repair.  

As specialists in the treatment of osteoarthritis and cartilage repair, we are experienced with most common treatments for OA disorders including joint arthroplasty and resurfacing, tissue grafting, scaffolding and marrow stimulation.  We use the latest imaging techniques for tissue visualization in combination with the appropriate systems to score the severity of arthritic disease such as MOCART, OARSI, WORMS, and Kellgren-Lawrence.   Our proprietary computer-assisted methods and internal classification atlases are routinely used to improve the reliability of our evaluations based on these grading systems.

MMI provides sponsors with a unique combination of clinical expertise, awareness of the latest advances in orthopedic imaging and understanding of current regulatory requirements and trends.  Our core group of clinical and scientific experts is led by Dr. Timothy Mosher and Dr. Sharmila Majumdar.

Timothy Mosher, MD

• Chief of Musculoskeletal Imaging and Clinical Director of MRI at Penn State University
• Fellowship trained in clinical MRI imaging at Johns Hopkins University
• Over 15 years of clinical experience in evaluating orthopedic imaging 
• Research is focused on development of quantitative MRI biomarkers of articular cartilage injury with application to the study of cartilage physiology and in vivo biomechanics.  
• Published over 50 articles, books and book chapters related to imaging of orthopedic treatments 
• Serves in editorial capacity at Magnetic Resonance in Medicine, Osteoarthritis and Cartilage, and Radiology