Neurology

Comprehensive Imaging Expertise for CNS Clinical Trials

Medical Metrics is an experienced provider of neuroimaging core lab services for clinical trials of CNS drugs and neurovascular and neuro-electrophysiological devices. Our team of neurologists, neuroradiologists, imaging scientists, engineers, and project staff understands the complexities of imaging-intensive neurology trials. Our neuroimaging services include multi-modal endpoint consulting, quantitative image analysis, independent blinded reads by neuroradiologists, and scientific/clinical consulting and data interpretation expertise for CNS treatments.

Experience and Expertise

Our neuroimaging portfolio includes investigations of the following pathologies:

  • Neuro-degenerative Diseases (Alzheimer’s, Parkinson’s, and ALS)
  • Stroke and Neurovascular Disease
  • Brain Neoplasms (Malignant Glioma and Metastatic Disease)
  • Multiple Sclerosis (MS)
  • Epilepsy
  • Psychiatric Diseases (Schizophrenia / Schizoaffective and Bipolar Disorders)

MMI’s technical and operations staff includes PhD-level managers with vast experience in neurology clinical trials ranging from small phase I studies to large global studies, including:

  • Anti-angiogenic and oncolytic virus therapies for malignant brain tumors
  • Neuronal physiology and metabolite variation studies in brain tumors, epilepsy, and schizophrenia
  • Tractography and white-matter studies of brain tumors, epilepsy, MS and ALS
  • Lesion, hippocampal, and brain volume/atrophy analysis in MS, epilepsy, and Alzheimer’s disease
  • Iron deposition in Parkinson’s disease
  • Advanced quantitative image analysis for epilepsy, MS, and Parkinson’s 
  • Immuno-, Gamma secratase, and Tau inhibitor therapies for Alzheimer’s 
  • PET and SPECT analysis in epilepsy

We work with sponsors of clinical trials to implement treatment-specific endpoints that are tailored to the unique mechanism of action of each investigational treatment. Brain Tumor studies, for example, have included standard evaluations such as RECIST and McDonald/WHO assessments in addition to advanced functional imaging surrogates such as permeability and perfusion derived from DCE/DSC-MRI, diffusion weighted-MRI, or MR Spectroscopy. We also utilize proprietary methods for volumetric analysis and characterization of tumors, gray- and white-matter, and pathological lesions.

MMI’s breadth of expertise in neuroimaging clinical trials includes the following modalities and endpoints:

Magnetic Resonance Imaging

  • DCE-Permeability & KTrans
  • DSC-MRI based computation of Cerebral Blood Volume & Flow
  • Apparent Diffusion Coefficient
  • Brain Volume and AtrophyLesion Burden
  • Perfusion-Diffusion Mismatch
  • MR Relaxometry (T1 / T2 / T1r)
  • WHO / McDonald / RECIST-based grading of lesions

Computed Tomography

  • Brain Perfusion & Hemodynamics
  • Ischemia and Infarct Characterization
  • AV Malformations and Aneurysm Analysis

PET / SPECT

  • Glucose Metabolism
  • Neurotransmitter & Tracer Uptake Studies
  • Radionuclide Activity Levels and Counts

Scientific Qualifications

Our medical image management experts have published novel image-processing techniques for characterizing various neurological and neuro-oncological treatments. This experience is available for additional offerings such as development of independent image review charters (IRCs), image acquisition protocols, guidance on issues such as imaging physics and QA, and interpretative assistance related to radiological outcomes. MMI’s panel of neuroradiologists consists of fellowship-trained physicians who are well-published and hold academic and/or research appointments at institutions of the Texas Medical Center. Working with MMI provides you the assurance of years of experience with neuroimaging technique development, image post-processing, analyses, imaging physics, and disease-specific treatments and endpoints.

MMI’s scientific staff and neuro-radiologists have contributed to the scientific literature and published extensively in leading journals such as Magnetic Resonance in Medicine, NeuroImage, Journal of Magnetic Resonance Imaging, Annals of Neurology, Journal of Clinical Oncology, Journal of Neuroimaging, American Journal of Neuroradiology, Magnetic Resonance Imaging, and Journal of Neurosurgery.